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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPAPDC1A All Species: 16.67
Human Site: Y226 Identified Species: 26.19
UniProt: Q5VZY2 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5VZY2 NP_001025230.1 271 30395 Y226 Y I C Y R Q H Y P P L A N T A
Chimpanzee Pan troglodytes XP_001170623 223 25141 G179 V L V G S M I G M T F A Y V C
Rhesus Macaque Macaca mulatta XP_001092746 343 37863 K285 L S R T C D Y K H H W Q D V L
Dog Lupus familis XP_535038 333 36609 Y288 Y I C Y R Q H Y P P L A N T A
Cat Felis silvestris
Mouse Mus musculus Q0VBU9 271 30425 Y226 Y I C Y R Q H Y P P L A N T A
Rat Rattus norvegicus O08564 282 31978 H224 R V S D Y K H H W S D V L I G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514919 461 51675 H232 H V P G D P R H P I T P P R G
Chicken Gallus gallus XP_426544 322 36285 Y277 Y I C Y R Q H Y P P L G N T A
Frog Xenopus laevis Q6GQ62 226 25153 F182 G A F I G L F F A F L C Y R Q
Zebra Danio Brachydanio rerio XP_002664129 282 31516 Y233 Y I C Y R Q H Y P P F L H I D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623887 268 30640 L223 G S I I G Y F L A Y M C Y R Y
Nematode Worm Caenorhab. elegans Q10022 341 39009 F277 C T F W T D L F S N N S T E S
Sea Urchin Strong. purpuratus XP_787511 258 29394 F213 Y A I Y R Q Y F P A L T H A T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9XI60 290 32684 F245 T F C Y L Q F F P P P Y D P D
Baker's Yeast Sacchar. cerevisiae Q05521 289 33495 F242 G Y I M A H F F Y R R I F P P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 51.2 48 77.7 N.A. 99.2 25.5 N.A. 48.1 77.3 52.4 71.2 N.A. N.A. 47.9 24.3 46.1
Protein Similarity: 100 64.9 60 79.8 N.A. 99.2 41.1 N.A. 53.3 80.4 63.4 83.6 N.A. N.A. 66.7 39.8 64.2
P-Site Identity: 100 6.6 0 100 N.A. 100 6.6 N.A. 6.6 93.3 6.6 66.6 N.A. N.A. 0 0 40
P-Site Similarity: 100 13.3 13.3 100 N.A. 100 26.6 N.A. 26.6 93.3 13.3 73.3 N.A. N.A. 6.6 26.6 60
Percent
Protein Identity: N.A. N.A. N.A. 36.5 31.1 N.A.
Protein Similarity: N.A. N.A. N.A. 54.4 50.5 N.A.
P-Site Identity: N.A. N.A. N.A. 33.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 46.6 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 14 0 0 7 0 0 0 14 7 0 27 0 7 27 % A
% Cys: 7 0 40 0 7 0 0 0 0 0 0 14 0 0 7 % C
% Asp: 0 0 0 7 7 14 0 0 0 0 7 0 14 0 14 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % E
% Phe: 0 7 14 0 0 0 27 34 0 7 14 0 7 0 0 % F
% Gly: 20 0 0 14 14 0 0 7 0 0 0 7 0 0 14 % G
% His: 7 0 0 0 0 7 40 14 7 7 0 0 14 0 0 % H
% Ile: 0 34 20 14 0 0 7 0 0 7 0 7 0 14 0 % I
% Lys: 0 0 0 0 0 7 0 7 0 0 0 0 0 0 0 % K
% Leu: 7 7 0 0 7 7 7 7 0 0 40 7 7 0 7 % L
% Met: 0 0 0 7 0 7 0 0 7 0 7 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 7 7 0 27 0 0 % N
% Pro: 0 0 7 0 0 7 0 0 54 40 7 7 7 14 7 % P
% Gln: 0 0 0 0 0 47 0 0 0 0 0 7 0 0 7 % Q
% Arg: 7 0 7 0 40 0 7 0 0 7 7 0 0 20 0 % R
% Ser: 0 14 7 0 7 0 0 0 7 7 0 7 0 0 7 % S
% Thr: 7 7 0 7 7 0 0 0 0 7 7 7 7 27 7 % T
% Val: 7 14 7 0 0 0 0 0 0 0 0 7 0 14 0 % V
% Trp: 0 0 0 7 0 0 0 0 7 0 7 0 0 0 0 % W
% Tyr: 40 7 0 47 7 7 14 34 7 7 0 7 20 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _